A prevention program that has been designated as a best practice means:

A prevention program designated as a best practice signifies that it has undergone rigorous research and evaluation demonstrating its effectiveness in achieving desired outcomes. This designation is often based on the program’s ability to consistently produce positive results in preventing substance abuse or related issues, making it well-supported by empirical evidence.

This means that the strategies and methodologies employed in the program have been tested and validated through scientific studies and evaluations, ensuring they deliver measurable improvements in the community or population targeted. The emphasis on research-backed effectiveness allows stakeholders—such as funders, program implementers, and community members—to have confidence in the program as a reliable approach to prevention efforts.

The other options, while important aspects of program implementation and relevance, do not specifically define what constitutes a best practice. Adaptation by other programs, cultural sensitivity, and involvement of experienced personnel are all valuable but do not, in themselves, guarantee that a program has been validated through effectiveness research.